E-ISSN 2090-0503 | ISSN 1687-7497
 
2023, Vol: 19, Issue: 2
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Original Research 


KLEBSIELLA PNEUMONIAE INVASION, ADHERENCE AND CYTOTOXICITY ARE INDEPENDENT EVENTS MECHANISMS

Madeha O.I. Ghobashy Hala M. Abu shady Samar S. Rashad Aisha M. A. Shahlol.

Abstract
Klebsiella pneumoniae is a member of the pathogenic group which causes a variety of human disease and outbreak problem in Hospitals. These organisms challenged the treatment by multidrug resistance. Furthermore, to develop new strategies and prevent bacterial pathogen outbreak must be studying virulence mechanisms, virulence factors and role of these factors in pathogenicity. Fifty K. pneumoniae isolates were recovered from different collected clinical specimens from Ain Sham Specialized (Ksp) and Al-Damardash Hospitals (KD) Cairo, Egypt, also from Sabha medical center Hospital (Ksa) Sabha, Libya. Isolates were identified by phenotypic and physiological methods by using API 20 E system. In general, the K. pneumoniae (KD & Ksp) isolates displayed higher adherence rate to Vero cells and cytotoxicity too. These results were exhibited significantly (P>0.05). Twenty percent were at higher adherence range (>8%) and 16% of cytotoxicity at very high level (<75%). On contrary, K. pneumoniae (Ksa) was demonstrated adherence rate by less ability (7%) at higher adherence range and (18%) to cytotoxicity at low level (>50%) by none significantly (P<0.05). Interestingly, invasion action for almost wild type strains was less effective on Vero cells. Additionally statistical significant correlation (P>0.05) was between adherence and invasion results for K. pneumoniae (KD & Ksp) and (Ksa) strains. Finally, we showed that both wild type strains were able to resistant serum killing by a resistance rate of 64% and 80%, while intermediate was resistance by 36% and 12%, respectively.

Key words: K. pneumoniae, Invasion, Adherence, Cytotoxicity, Serum resistant, Capsule


 
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How to Cite this Article
Pubmed Style

Madeha O.I. Ghobashy Hala M. Abu shady Samar S. Rashad Aisha M. A. Shahlol. KLEBSIELLA PNEUMONIAE INVASION, ADHERENCE AND CYTOTOXICITY ARE INDEPENDENT EVENTS MECHANISMS. Egypt. J. Exp. Biol. (Bot.). 2012; 8(2): 251-259.

Web Style

Madeha O.I. Ghobashy Hala M. Abu shady Samar S. Rashad Aisha M. A. Shahlol. KLEBSIELLA PNEUMONIAE INVASION, ADHERENCE AND CYTOTOXICITY ARE INDEPENDENT EVENTS MECHANISMS. https://www.egyseb.net//?mno=186915 [Access: December 05, 2023].

AMA (American Medical Association) Style

Madeha O.I. Ghobashy Hala M. Abu shady Samar S. Rashad Aisha M. A. Shahlol. KLEBSIELLA PNEUMONIAE INVASION, ADHERENCE AND CYTOTOXICITY ARE INDEPENDENT EVENTS MECHANISMS. Egypt. J. Exp. Biol. (Bot.). 2012; 8(2): 251-259.


Vancouver/ICMJE Style

Madeha O.I. Ghobashy Hala M. Abu shady Samar S. Rashad Aisha M. A. Shahlol. KLEBSIELLA PNEUMONIAE INVASION, ADHERENCE AND CYTOTOXICITY ARE INDEPENDENT EVENTS MECHANISMS. Egypt. J. Exp. Biol. (Bot.). (2012), [cited December 05, 2023]; 8(2): 251-259.


Harvard Style

Madeha O.I. Ghobashy Hala M. Abu shady Samar S. Rashad Aisha M. A. Shahlol (2012) KLEBSIELLA PNEUMONIAE INVASION, ADHERENCE AND CYTOTOXICITY ARE INDEPENDENT EVENTS MECHANISMS. Egypt. J. Exp. Biol. (Bot.), 8 (2), 251-259.


Turabian Style

Madeha O.I. Ghobashy Hala M. Abu shady Samar S. Rashad Aisha M. A. Shahlol. 2012. KLEBSIELLA PNEUMONIAE INVASION, ADHERENCE AND CYTOTOXICITY ARE INDEPENDENT EVENTS MECHANISMS. THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Botany), 8 (2), 251-259.


Chicago Style

Madeha O.I. Ghobashy Hala M. Abu shady Samar S. Rashad Aisha M. A. Shahlol. "KLEBSIELLA PNEUMONIAE INVASION, ADHERENCE AND CYTOTOXICITY ARE INDEPENDENT EVENTS MECHANISMS." THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Botany) 8 (2012), 251-259.


MLA (The Modern Language Association) Style

Madeha O.I. Ghobashy Hala M. Abu shady Samar S. Rashad Aisha M. A. Shahlol. "KLEBSIELLA PNEUMONIAE INVASION, ADHERENCE AND CYTOTOXICITY ARE INDEPENDENT EVENTS MECHANISMS." THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Botany) 8.2 (2012), 251-259. Print.


APA (American Psychological Association) Style

Madeha O.I. Ghobashy Hala M. Abu shady Samar S. Rashad Aisha M. A. Shahlol (2012) KLEBSIELLA PNEUMONIAE INVASION, ADHERENCE AND CYTOTOXICITY ARE INDEPENDENT EVENTS MECHANISMS. THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Botany), 8 (2), 251-259.


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