E-ISSN 2090-0503 | ISSN 1687-7497
 
2023, Vol: 19, Issue: 2
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Original Research 


IN VITRO ANTIFUNGAL DRUG SUSCEPTIBILITY OF DERMATOPHYTES ISOLATED FROM PATIENTS IN AL-MEDINA, SAUDI ARABIA

Ahmed Medhat Hanafy.

Abstract
The antifungal activities of seven commercially available antifungal drugs (fluconazole, itraconazole, ketoconazole, miconazole, clotrimazole, terbinafine and griseofulvin) were evaluated by broth micro-dilution method as proposed by the Clinical and Laboratory Standards Institute (CLSI), against 70 dermatophyte isolates from hair, skin and nail specimens of patients with cutenous mycosis in Al-Medina city, Saudi Arabia. In this study, the microtiter plates were incubated at 28ºC allowing a reading of the minimal inhibitory concentration (MIC) after four to five days of incubation. In vitro antifungal drug susceptibility studies showed that most of the dermatophytes had uniform patterns of susceptibility towards the tested antifungal agents. Of these antifungal agents, the best results in terms of sensitivity were found with terbinafine and clotrimazole, while the anti fungal activity of fluconazole and griseofulvin was found to be weak, particularly against strains of Trichophyton verrucosum. Although less effective than terbinafine and clotrimazole still the remaining four antifungal agents (itraconazole, ketoconazole and miconazole) also yielded satisfactory results.

Key words: Dermatophytes, antifungal agents, broth micro-dilution method, drug susceptibility test, minimal Inhibitory concentration (MIC).


 
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Pubmed Style

Ahmed Medhat Hanafy. IN VITRO ANTIFUNGAL DRUG SUSCEPTIBILITY OF DERMATOPHYTES ISOLATED FROM PATIENTS IN AL-MEDINA, SAUDI ARABIA . Egypt. J. Exp. Biol. (Bot.). 2012; 8(2): 245-250.

Web Style

Ahmed Medhat Hanafy. IN VITRO ANTIFUNGAL DRUG SUSCEPTIBILITY OF DERMATOPHYTES ISOLATED FROM PATIENTS IN AL-MEDINA, SAUDI ARABIA . https://www.egyseb.net//?mno=186914 [Access: August 15, 2023].

AMA (American Medical Association) Style

Ahmed Medhat Hanafy. IN VITRO ANTIFUNGAL DRUG SUSCEPTIBILITY OF DERMATOPHYTES ISOLATED FROM PATIENTS IN AL-MEDINA, SAUDI ARABIA . Egypt. J. Exp. Biol. (Bot.). 2012; 8(2): 245-250.


Vancouver/ICMJE Style

Ahmed Medhat Hanafy. IN VITRO ANTIFUNGAL DRUG SUSCEPTIBILITY OF DERMATOPHYTES ISOLATED FROM PATIENTS IN AL-MEDINA, SAUDI ARABIA . Egypt. J. Exp. Biol. (Bot.). (2012), [cited August 15, 2023]; 8(2): 245-250.


Harvard Style

Ahmed Medhat Hanafy (2012) IN VITRO ANTIFUNGAL DRUG SUSCEPTIBILITY OF DERMATOPHYTES ISOLATED FROM PATIENTS IN AL-MEDINA, SAUDI ARABIA . Egypt. J. Exp. Biol. (Bot.), 8 (2), 245-250.


Turabian Style

Ahmed Medhat Hanafy. 2012. IN VITRO ANTIFUNGAL DRUG SUSCEPTIBILITY OF DERMATOPHYTES ISOLATED FROM PATIENTS IN AL-MEDINA, SAUDI ARABIA . THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Botany), 8 (2), 245-250.


Chicago Style

Ahmed Medhat Hanafy. "IN VITRO ANTIFUNGAL DRUG SUSCEPTIBILITY OF DERMATOPHYTES ISOLATED FROM PATIENTS IN AL-MEDINA, SAUDI ARABIA ." THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Botany) 8 (2012), 245-250.


MLA (The Modern Language Association) Style

Ahmed Medhat Hanafy. "IN VITRO ANTIFUNGAL DRUG SUSCEPTIBILITY OF DERMATOPHYTES ISOLATED FROM PATIENTS IN AL-MEDINA, SAUDI ARABIA ." THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Botany) 8.2 (2012), 245-250. Print.


APA (American Psychological Association) Style

Ahmed Medhat Hanafy (2012) IN VITRO ANTIFUNGAL DRUG SUSCEPTIBILITY OF DERMATOPHYTES ISOLATED FROM PATIENTS IN AL-MEDINA, SAUDI ARABIA . THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Botany), 8 (2), 245-250.


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