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THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Zoology)
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The effect of stevia sweetener on diabetic nephropathy in rats|
E-ISSN 2090-0503 | ISSN 2090-0511
 

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Original Research 


The effect of stevia sweetener on diabetic nephropathy in rats

Azza Mohamed Marei , Doaa Ismail Mahmoud.

Abstract
Diabetic nephropathy (DN) is considered a clinical syndrome, which is a diabetic kidney disease characterized by increasing blood pressure, albuminuria, and chronic kidney disease. The current study aimed to determine the effect of sweetener (Stevia rebaudiana ) on diabetic nephropathy in a diabetic rat model. Four groups (n=7) of male albino rats (Rattus norvegicus): the control group, diabetic control group (induced streptozotocin intraperitoneally), two diabetic rat groups treated with 2 doses of stevia (200 and 400 mg/kg body weight) for 4 weeks. Biomarkers of nephropathy were measured in plasma and kidneys at the end of the experiment. The levels of plasma glucose, urea, uric acid, creatinine, renal malondialdehyde (MDA), and caspase-3 significantly increased in diabetic rats and levels of insulin, renal catalase, superoxide dismutase, and vascular endothelial growth factor A (VEGF-A) were significantly decreased. After treating the diabetic rats with natural sweetener (stevia), the kidney and plasma biochemical parameters were improved significantly. These results indicated the major role of stevia in diabetic nephropathy.

Key words: Diabetic nephropathy, natural sweetener, Stevia, Streptozotocin.


 
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Pubmed Style

AMM, Mahmoud DI, . The effect of stevia sweetener on diabetic nephropathy in rats. Egypt. J. Exp. Biol. (Zoo.). 2022; 18(2): 137-141. doi:10.5455/egysebz.20220803073155


Web Style

AMM, Mahmoud DI, . The effect of stevia sweetener on diabetic nephropathy in rats. https://www.egyseb.net/ejebz/?mno=95954 [Access: November 27, 2022]. doi:10.5455/egysebz.20220803073155


AMA (American Medical Association) Style

AMM, Mahmoud DI, . The effect of stevia sweetener on diabetic nephropathy in rats. Egypt. J. Exp. Biol. (Zoo.). 2022; 18(2): 137-141. doi:10.5455/egysebz.20220803073155



Vancouver/ICMJE Style

AMM, Mahmoud DI, . The effect of stevia sweetener on diabetic nephropathy in rats. Egypt. J. Exp. Biol. (Zoo.). (2022), [cited November 27, 2022]; 18(2): 137-141. doi:10.5455/egysebz.20220803073155



Harvard Style

, A. M. M., Mahmoud, D. I. & (2022) The effect of stevia sweetener on diabetic nephropathy in rats. Egypt. J. Exp. Biol. (Zoo.), 18 (2), 137-141. doi:10.5455/egysebz.20220803073155



Turabian Style

, Azza Mohamed Marei, Doaa Ismail Mahmoud, and . 2022. The effect of stevia sweetener on diabetic nephropathy in rats. THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Zoology), 18 (2), 137-141. doi:10.5455/egysebz.20220803073155



Chicago Style

, Azza Mohamed Marei, Doaa Ismail Mahmoud, and . "The effect of stevia sweetener on diabetic nephropathy in rats." THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Zoology) 18 (2022), 137-141. doi:10.5455/egysebz.20220803073155



MLA (The Modern Language Association) Style

, Azza Mohamed Marei, Doaa Ismail Mahmoud, and . "The effect of stevia sweetener on diabetic nephropathy in rats." THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Zoology) 18.2 (2022), 137-141. Print. doi:10.5455/egysebz.20220803073155



APA (American Psychological Association) Style

, A. M. M., Mahmoud, D. I. & (2022) The effect of stevia sweetener on diabetic nephropathy in rats. THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Zoology), 18 (2), 137-141. doi:10.5455/egysebz.20220803073155