E-ISSN 2090-0503 | ISSN 2090-0511
 

Original Research 


Adverse effects of therapeutic doses of sofosbuvir and ribavirin on the liver of the developing mice embryos

Esraa H Shahat, Hamza A. El Shabaka, Iman Zakaria, Suzan Ahmed.

Abstract
The aim of this study was to investigate the adverse effect of Sofosbuvir (SFV) and / or Ribavirin (RBV) on developing mice embryos in order to determine the morphological and the liver tissue alterations of mice fetuses. The pregnant mice were divided into eight groups: 1) control group (GI); 2) SFV 1.64 mg/mouse/day (GII); 3) SFV 4.93 mg/mouse/day (GIII); 4) RBV 0.2065 mg/mouse/day (GIV); 5) RBV 0.856 mg/mouse/day (GV); 6) SFV 1.64 mg/mouse/day and RBV 0.856 mg/mouse/day (GVI); 7) SFV 4.93 mg/mouse/day and RBV 0.856 mg/mouse/day (GVII) and 8) SFV 1.64 mg/mouse/day and RBV 0.2065 mg/mouse/day (GVIII). Maternal exposure of both drugs SFV and/or RBV affected the body weight, number of fetuses and presence of resorption sites. A variety of morphological abnormalities were detected in all groups demonstrating several craniofacial malformations and conspicuous congenital malformations. The most pronounced effects in (GV) were the detection of exencephaly and facial condition. The liver of the maternally treated fetuses of (GII) and (GIV) revealed necrotic hepatocytes with vacuolated cytoplasm. While (GIII) and (GV) revealed hepatocytes degeneration, damaged endothelial cells lining the central veins and the presence of activated Kupffer cells.

Key words: Sofosbuvir, Ribavirin, morphological studies, liver, histological examination, embryo.


 
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How to Cite this Article
Pubmed Style

Shahat EH, Shabaka HAE, IZ, Ahmed S. Adverse effects of therapeutic doses of sofosbuvir and ribavirin on the liver of the developing mice embryos. Egypt. J. Exp. Biol. (Zoo.). 2021; 17(1): 51-66. doi:10.5455/egysebz.20210706095316


Web Style

Shahat EH, Shabaka HAE, IZ, Ahmed S. Adverse effects of therapeutic doses of sofosbuvir and ribavirin on the liver of the developing mice embryos. http://www.egyseb.net/ejebz/?mno=93934 [Access: October 26, 2021]. doi:10.5455/egysebz.20210706095316


AMA (American Medical Association) Style

Shahat EH, Shabaka HAE, IZ, Ahmed S. Adverse effects of therapeutic doses of sofosbuvir and ribavirin on the liver of the developing mice embryos. Egypt. J. Exp. Biol. (Zoo.). 2021; 17(1): 51-66. doi:10.5455/egysebz.20210706095316



Vancouver/ICMJE Style

Shahat EH, Shabaka HAE, IZ, Ahmed S. Adverse effects of therapeutic doses of sofosbuvir and ribavirin on the liver of the developing mice embryos. Egypt. J. Exp. Biol. (Zoo.). (2021), [cited October 26, 2021]; 17(1): 51-66. doi:10.5455/egysebz.20210706095316



Harvard Style

Shahat, E. H., Shabaka, . H. A. E., , . I. Z. & Ahmed, . S. (2021) Adverse effects of therapeutic doses of sofosbuvir and ribavirin on the liver of the developing mice embryos. Egypt. J. Exp. Biol. (Zoo.), 17 (1), 51-66. doi:10.5455/egysebz.20210706095316



Turabian Style

Shahat, Esraa H, Hamza A. El Shabaka, Iman Zakaria, and Suzan Ahmed. 2021. Adverse effects of therapeutic doses of sofosbuvir and ribavirin on the liver of the developing mice embryos. THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Zoology), 17 (1), 51-66. doi:10.5455/egysebz.20210706095316



Chicago Style

Shahat, Esraa H, Hamza A. El Shabaka, Iman Zakaria, and Suzan Ahmed. "Adverse effects of therapeutic doses of sofosbuvir and ribavirin on the liver of the developing mice embryos." THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Zoology) 17 (2021), 51-66. doi:10.5455/egysebz.20210706095316



MLA (The Modern Language Association) Style

Shahat, Esraa H, Hamza A. El Shabaka, Iman Zakaria, and Suzan Ahmed. "Adverse effects of therapeutic doses of sofosbuvir and ribavirin on the liver of the developing mice embryos." THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Zoology) 17.1 (2021), 51-66. Print. doi:10.5455/egysebz.20210706095316



APA (American Psychological Association) Style

Shahat, E. H., Shabaka, . H. A. E., , . I. Z. & Ahmed, . S. (2021) Adverse effects of therapeutic doses of sofosbuvir and ribavirin on the liver of the developing mice embryos. THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Zoology), 17 (1), 51-66. doi:10.5455/egysebz.20210706095316