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Effects of two local anesthetics (Mepivacaine - Articaine) on histological features of submandibular salivary gland and thyroid hormones of experimental animals

Kadria Elkasheif, Noha Awad, Ibrahim Elhalafawy, Mostufa samad, Hisham Ismail.

Abstract
Background: To examine the histological features of the hamster's submandibular salivary gland following the administration of mepivacaine and articaine as local anaesthetics Objective: The purpose of this study is to assess the anaesthetic effectiveness of both anaesthetics on thyroid hormonal levels and the histopathological changes of the gland. Materials and Methods: Twenty-four male hamsters were divided into three groups. The submandibular glands were removed and preserved in 10% phosphate buffered formalin (PH7.4) for histological investigation, while Group B and C (each of eight animals) received injections of mepivacine and articaine 2% HCl local anaesthetic at a rate of 0.05 ml per second four times after administration. In order to evaluate the amounts of the hormones triiodothyronine (T3) and thyroxin in the blood samples collected (T4)
Results: Salivary gland histology using light microscopy revealed normal acini, striated ducts, and glanular ducts in group I, but atrophic changes in serous acini, a loss of acinar architecture, and congestion of inter-acinar blood capillaries in groups II and III, with the latter change being more pronounced in group III as a result of a longer induction period. Long-term use of mepivacaine and articaine medicines results in toxic effects and changes to the salivary glands that indicate stress and damage. When compared to the control, there was a statistically significant rise in T3 and TSH and a substantial drop in T4 in the experimental animals.

Key words: Histopathology, Local anesthetics, Mepivacaine, Articaine, Submandibular Salivary gland, Hamster.


 
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How to Cite this Article
Pubmed Style

KE, Awad N, Elhalafawy I, samad M, Ismail H. Effects of two local anesthetics (Mepivacaine - Articaine) on histological features of submandibular salivary gland and thyroid hormones of experimental animals. Egypt. J. Exp. Biol. (Zoo.). 2023; 19(1): 43-50. doi:10.5455/egysebz.20220919082539

Web Style

KE, Awad N, Elhalafawy I, samad M, Ismail H. Effects of two local anesthetics (Mepivacaine - Articaine) on histological features of submandibular salivary gland and thyroid hormones of experimental animals. https://www.egyseb.net/ejebz/?mno=115466 [Access: June 03, 2023]. doi:10.5455/egysebz.20220919082539

AMA (American Medical Association) Style

KE, Awad N, Elhalafawy I, samad M, Ismail H. Effects of two local anesthetics (Mepivacaine - Articaine) on histological features of submandibular salivary gland and thyroid hormones of experimental animals. Egypt. J. Exp. Biol. (Zoo.). 2023; 19(1): 43-50. doi:10.5455/egysebz.20220919082539


Vancouver/ICMJE Style

KE, Awad N, Elhalafawy I, samad M, Ismail H. Effects of two local anesthetics (Mepivacaine - Articaine) on histological features of submandibular salivary gland and thyroid hormones of experimental animals. Egypt. J. Exp. Biol. (Zoo.). (2023), [cited June 03, 2023]; 19(1): 43-50. doi:10.5455/egysebz.20220919082539


Harvard Style

, K. E., Awad, . N., Elhalafawy, . I., samad, . M. & Ismail, . H. (2023) Effects of two local anesthetics (Mepivacaine - Articaine) on histological features of submandibular salivary gland and thyroid hormones of experimental animals. Egypt. J. Exp. Biol. (Zoo.), 19 (1), 43-50. doi:10.5455/egysebz.20220919082539


Turabian Style

, Kadria Elkasheif, Noha Awad, Ibrahim Elhalafawy, Mostufa samad, and Hisham Ismail. 2023. Effects of two local anesthetics (Mepivacaine - Articaine) on histological features of submandibular salivary gland and thyroid hormones of experimental animals. THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Zoology), 19 (1), 43-50. doi:10.5455/egysebz.20220919082539


Chicago Style

, Kadria Elkasheif, Noha Awad, Ibrahim Elhalafawy, Mostufa samad, and Hisham Ismail. "Effects of two local anesthetics (Mepivacaine - Articaine) on histological features of submandibular salivary gland and thyroid hormones of experimental animals." THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Zoology) 19 (2023), 43-50. doi:10.5455/egysebz.20220919082539


MLA (The Modern Language Association) Style

, Kadria Elkasheif, Noha Awad, Ibrahim Elhalafawy, Mostufa samad, and Hisham Ismail. "Effects of two local anesthetics (Mepivacaine - Articaine) on histological features of submandibular salivary gland and thyroid hormones of experimental animals." THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Zoology) 19.1 (2023), 43-50. Print. doi:10.5455/egysebz.20220919082539


APA (American Psychological Association) Style

, K. E., Awad, . N., Elhalafawy, . I., samad, . M. & Ismail, . H. (2023) Effects of two local anesthetics (Mepivacaine - Articaine) on histological features of submandibular salivary gland and thyroid hormones of experimental animals. THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Zoology), 19 (1), 43-50. doi:10.5455/egysebz.20220919082539


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