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THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Zoology)
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Role of Gymnema sylvestre leaf extract on hepatotoxicity induced by cisplatin in rats|
E-ISSN 2090-0503 | ISSN 2090-0511
 

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Original Research 


Role of Gymnema sylvestre leaf extract on hepatotoxicity induced by cisplatin in rats

Doaa Sabry Ibrahim.

Abstract
Cisplatin (CP) is a common antitumor drug that has many side effects, one of which is hepatotoxicity. Oxidative stress induced by CP is the main mechanism it uses to cause hepatotoxicity. So, the research aims to investigate whether the antioxidant-rich Gymnema sylvestre leaf extract (GSLE) could ameliorate CP-induced hepatotoxicity. Five groups of six rats each were used in the trial: the control group, the GSLE group received orally 100 mg/kg BW, the CP group injected with a single intraperitoneal dose of 5 mg/kg BW, the CP + GSLE group and the GSLE + CP group. Sera and livers of rats were taken after 12 days (experiment duration) to evaluate biochemical markers and hepatic histopathological modifications. The hepatic levels of malondialdehyde (MDA), nuclear factor-kappa B (NF-κB), tumor necrosis factor-alpha (TNF-α), and caspases (8, 9, and 12), as well as serum liver function biomarkers (ALT, AST, and TBIL), were all raised after CP injection. Furthermore, CP reduced the hepatic activities of antioxidant enzymes (CAT and SOD) and caused hepatic damage in the form of hydropic, vacuolar, and fatty degeneration of hepatocytes. Meanwhile, GSLE administration reduced hepatic levels of MDA, NF-κB, TNF-α, caspases, and serum liver function biomarkers. Also, GSLE administration increased the hepatic activities of antioxidant enzymes and reduced the histopathological changes in hepatocytes. It can be concluded that the GSLE has the potential to counteract CP hepatotoxicity by decreasing the free radicals, inflammation, and apoptosis induced by CP.

Key words: Cisplatin; Gymnema sylvestre leaf extract; liver function biomarkers; hepatic oxidative stress; hepatic apoptosis


 
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How to Cite this Article
Pubmed Style

Doaa Sabry Ibrahim. Role of Gymnema sylvestre leaf extract on hepatotoxicity induced by cisplatin in rats. Egypt. J. Exp. Biol. (Zoo.). 2022; 18(2): 163-170. doi:10.5455/egysebz.20220820103856


Web Style

Doaa Sabry Ibrahim. Role of Gymnema sylvestre leaf extract on hepatotoxicity induced by cisplatin in rats. https://www.egyseb.net/ejebz/?mno=107639 [Access: November 27, 2022]. doi:10.5455/egysebz.20220820103856


AMA (American Medical Association) Style

Doaa Sabry Ibrahim. Role of Gymnema sylvestre leaf extract on hepatotoxicity induced by cisplatin in rats. Egypt. J. Exp. Biol. (Zoo.). 2022; 18(2): 163-170. doi:10.5455/egysebz.20220820103856



Vancouver/ICMJE Style

Doaa Sabry Ibrahim. Role of Gymnema sylvestre leaf extract on hepatotoxicity induced by cisplatin in rats. Egypt. J. Exp. Biol. (Zoo.). (2022), [cited November 27, 2022]; 18(2): 163-170. doi:10.5455/egysebz.20220820103856



Harvard Style

Doaa Sabry Ibrahim (2022) Role of Gymnema sylvestre leaf extract on hepatotoxicity induced by cisplatin in rats. Egypt. J. Exp. Biol. (Zoo.), 18 (2), 163-170. doi:10.5455/egysebz.20220820103856



Turabian Style

Doaa Sabry Ibrahim. 2022. Role of Gymnema sylvestre leaf extract on hepatotoxicity induced by cisplatin in rats. THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Zoology), 18 (2), 163-170. doi:10.5455/egysebz.20220820103856



Chicago Style

Doaa Sabry Ibrahim. "Role of Gymnema sylvestre leaf extract on hepatotoxicity induced by cisplatin in rats." THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Zoology) 18 (2022), 163-170. doi:10.5455/egysebz.20220820103856



MLA (The Modern Language Association) Style

Doaa Sabry Ibrahim. "Role of Gymnema sylvestre leaf extract on hepatotoxicity induced by cisplatin in rats." THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Zoology) 18.2 (2022), 163-170. Print. doi:10.5455/egysebz.20220820103856



APA (American Psychological Association) Style

Doaa Sabry Ibrahim (2022) Role of Gymnema sylvestre leaf extract on hepatotoxicity induced by cisplatin in rats. THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Zoology), 18 (2), 163-170. doi:10.5455/egysebz.20220820103856