E-ISSN 2090-0503 | ISSN 1687-7497
 
2023, Vol: 19, Issue: 2
19 / 2Current Issue Online FirstArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles

Original Research 


Selective toxicity of mycosynthesized zinc nanoparticles toward colon cancer and its most associative pathogen (Streptococcus gallolyticus)

Marwa Mostafa Abdel-Aziz, Nesreen Ahmed Safwat, Basma Hamdy Amin.

Abstract
Colon cancer is one of the most common causes of cancer-related deaths worldwide. Streptococcus bovis (currently Streptococcus gallolyticus) is considered a silent sign of colon malignancy diseases. As best of our knowledge this study is the first report dealt with collective elimination of colon cancer and its most associative pathogen (S. gallolyticus). Few attempts have been made to investigate the feasibility of using fungi to synthesize ZnNPs. Biosynthesis of zinc nanoparticles using Epicoccum nigrum (ATCC 48203) was achieved in the current study. Mycosynthesized ZnNPs were characterized using UV-visible spectrophotometer, Energy Dispersive X-ray (EDX) and transmission electron microscope (TEM). Mycosynthesized ZnNPs exhibited promising antibacterial activity in vitro against S. gallolyticus which have been visualized using Scanning and transmission Electron Microscopes (SEM &TEM). Cytotoxicity profiles of malignant and normal colon cells treated with mycosynthesized ZnNPs in vitro suggested that ZnNPs exhibited a preferential ability to kill cancerous colon cells than normal colon cells as visualized by Inverted microscope, SEM and TEM. Selective cytotoxicity of ZnNPs might be due to increased Reactive Oxygen Species (ROS) generation % in HCT-116 and S. gallolyticus treated with ZnNPs compared with normal colon cells treated with ZnNPs. This finding makes ZnNPs a promising anticancer and antibacterial agent.

Key words: Mycosynthesis, Zinc nanoparticles, selective toxicity, anticancer, antibacterial, Reactive Oxygen Species.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Marwa Mostafa Abdel-Aziz
Articles by Nesreen Ahmed Safwat
Articles by Basma Hamdy Amin
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Marwa Mostafa Abdel-Aziz, Nesreen Ahmed Safwat, Basma Hamdy Amin. Selective toxicity of mycosynthesized zinc nanoparticles toward colon cancer and its most associative pathogen (Streptococcus gallolyticus). Egypt. J. Exp. Biol. (Bot.). 2018; 14(1): 133-142. doi:10.5455/egyjebb.20180213061231

Web Style

Marwa Mostafa Abdel-Aziz, Nesreen Ahmed Safwat, Basma Hamdy Amin. Selective toxicity of mycosynthesized zinc nanoparticles toward colon cancer and its most associative pathogen (Streptococcus gallolyticus). https://www.egyseb.net//?mno=291017 [Access: December 05, 2023]. doi:10.5455/egyjebb.20180213061231

AMA (American Medical Association) Style

Marwa Mostafa Abdel-Aziz, Nesreen Ahmed Safwat, Basma Hamdy Amin. Selective toxicity of mycosynthesized zinc nanoparticles toward colon cancer and its most associative pathogen (Streptococcus gallolyticus). Egypt. J. Exp. Biol. (Bot.). 2018; 14(1): 133-142. doi:10.5455/egyjebb.20180213061231


Vancouver/ICMJE Style

Marwa Mostafa Abdel-Aziz, Nesreen Ahmed Safwat, Basma Hamdy Amin. Selective toxicity of mycosynthesized zinc nanoparticles toward colon cancer and its most associative pathogen (Streptococcus gallolyticus). Egypt. J. Exp. Biol. (Bot.). (2018), [cited December 05, 2023]; 14(1): 133-142. doi:10.5455/egyjebb.20180213061231


Harvard Style

Marwa Mostafa Abdel-Aziz, Nesreen Ahmed Safwat, Basma Hamdy Amin (2018) Selective toxicity of mycosynthesized zinc nanoparticles toward colon cancer and its most associative pathogen (Streptococcus gallolyticus). Egypt. J. Exp. Biol. (Bot.), 14 (1), 133-142. doi:10.5455/egyjebb.20180213061231


Turabian Style

Marwa Mostafa Abdel-Aziz, Nesreen Ahmed Safwat, Basma Hamdy Amin. 2018. Selective toxicity of mycosynthesized zinc nanoparticles toward colon cancer and its most associative pathogen (Streptococcus gallolyticus). THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Botany), 14 (1), 133-142. doi:10.5455/egyjebb.20180213061231


Chicago Style

Marwa Mostafa Abdel-Aziz, Nesreen Ahmed Safwat, Basma Hamdy Amin. "Selective toxicity of mycosynthesized zinc nanoparticles toward colon cancer and its most associative pathogen (Streptococcus gallolyticus)." THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Botany) 14 (2018), 133-142. doi:10.5455/egyjebb.20180213061231


MLA (The Modern Language Association) Style

Marwa Mostafa Abdel-Aziz, Nesreen Ahmed Safwat, Basma Hamdy Amin. "Selective toxicity of mycosynthesized zinc nanoparticles toward colon cancer and its most associative pathogen (Streptococcus gallolyticus)." THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Botany) 14.1 (2018), 133-142. Print. doi:10.5455/egyjebb.20180213061231


APA (American Psychological Association) Style

Marwa Mostafa Abdel-Aziz, Nesreen Ahmed Safwat, Basma Hamdy Amin (2018) Selective toxicity of mycosynthesized zinc nanoparticles toward colon cancer and its most associative pathogen (Streptococcus gallolyticus). THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Botany), 14 (1), 133-142. doi:10.5455/egyjebb.20180213061231


Author LoginReviewer LoginAbout PublisherEditorial PoliciesEditorial Review PolicyPeer Review PolicyEditorial & Peer Review ProcessPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyProtection of Research Participants (Statement On Human And Animal Rights)Privacy PolicySelf-Archiving PoliciesTerms of UseLicense Information

About THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Botany)

The Egyptian Journal of Experimental Biology (Botany) publishes original scientific research concerning botanical sciences (Morphology, Taxonomy, Gen ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information

egysebbz@gmail.com