E-ISSN 2090-0503 | ISSN 1687-7497
 

Original Research 


Selective toxicity of mycosynthesized zinc nanoparticles toward colon cancer and its most associative pathogen (Streptococcus gallolyticus)

Marwa Mostafa Abdel-Aziz, Nesreen Ahmed Safwat, Basma Hamdy Amin.

Abstract
Colon cancer is one of the most common causes of cancer-related deaths worldwide. Streptococcus bovis (currently Streptococcus gallolyticus) is considered a silent sign of colon malignancy diseases. As best of our knowledge this study is the first report dealt with collective elimination of colon cancer and its most associative pathogen (S. gallolyticus). Few attempts have been made to investigate the feasibility of using fungi to synthesize ZnNPs. Biosynthesis of zinc nanoparticles using Epicoccum nigrum (ATCC 48203) was achieved in the current study. Mycosynthesized ZnNPs were characterized using UV-visible spectrophotometer, Energy Dispersive X-ray (EDX) and transmission electron microscope (TEM). Mycosynthesized ZnNPs exhibited promising antibacterial activity in vitro against S. gallolyticus which have been visualized using Scanning and transmission Electron Microscopes (SEM &TEM). Cytotoxicity profiles of malignant and normal colon cells treated with mycosynthesized ZnNPs in vitro suggested that ZnNPs exhibited a preferential ability to kill cancerous colon cells than normal colon cells as visualized by Inverted microscope, SEM and TEM. Selective cytotoxicity of ZnNPs might be due to increased Reactive Oxygen Species (ROS) generation % in HCT-116 and S. gallolyticus treated with ZnNPs compared with normal colon cells treated with ZnNPs. This finding makes ZnNPs a promising anticancer and antibacterial agent.

Key words: Mycosynthesis, Zinc nanoparticles, selective toxicity, anticancer, antibacterial, Reactive Oxygen Species.


 
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How to Cite this Article
Pubmed Style

Marwa Mostafa Abdel-Aziz, Nesreen Ahmed Safwat, Basma Hamdy Amin. Selective toxicity of mycosynthesized zinc nanoparticles toward colon cancer and its most associative pathogen (Streptococcus gallolyticus). Egypt. J. Exp. Biol. (Bot.). 2018; 14(1): 133-142. doi:10.5455/egyjebb.20180213061231


Web Style

Marwa Mostafa Abdel-Aziz, Nesreen Ahmed Safwat, Basma Hamdy Amin. Selective toxicity of mycosynthesized zinc nanoparticles toward colon cancer and its most associative pathogen (Streptococcus gallolyticus). http://www.egyseb.net//?mno=291017 [Access: November 03, 2020]. doi:10.5455/egyjebb.20180213061231


AMA (American Medical Association) Style

Marwa Mostafa Abdel-Aziz, Nesreen Ahmed Safwat, Basma Hamdy Amin. Selective toxicity of mycosynthesized zinc nanoparticles toward colon cancer and its most associative pathogen (Streptococcus gallolyticus). Egypt. J. Exp. Biol. (Bot.). 2018; 14(1): 133-142. doi:10.5455/egyjebb.20180213061231



Vancouver/ICMJE Style

Marwa Mostafa Abdel-Aziz, Nesreen Ahmed Safwat, Basma Hamdy Amin. Selective toxicity of mycosynthesized zinc nanoparticles toward colon cancer and its most associative pathogen (Streptococcus gallolyticus). Egypt. J. Exp. Biol. (Bot.). (2018), [cited November 03, 2020]; 14(1): 133-142. doi:10.5455/egyjebb.20180213061231



Harvard Style

Marwa Mostafa Abdel-Aziz, Nesreen Ahmed Safwat, Basma Hamdy Amin (2018) Selective toxicity of mycosynthesized zinc nanoparticles toward colon cancer and its most associative pathogen (Streptococcus gallolyticus). Egypt. J. Exp. Biol. (Bot.), 14 (1), 133-142. doi:10.5455/egyjebb.20180213061231



Turabian Style

Marwa Mostafa Abdel-Aziz, Nesreen Ahmed Safwat, Basma Hamdy Amin. 2018. Selective toxicity of mycosynthesized zinc nanoparticles toward colon cancer and its most associative pathogen (Streptococcus gallolyticus). THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Botany), 14 (1), 133-142. doi:10.5455/egyjebb.20180213061231



Chicago Style

Marwa Mostafa Abdel-Aziz, Nesreen Ahmed Safwat, Basma Hamdy Amin. "Selective toxicity of mycosynthesized zinc nanoparticles toward colon cancer and its most associative pathogen (Streptococcus gallolyticus)." THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Botany) 14 (2018), 133-142. doi:10.5455/egyjebb.20180213061231



MLA (The Modern Language Association) Style

Marwa Mostafa Abdel-Aziz, Nesreen Ahmed Safwat, Basma Hamdy Amin. "Selective toxicity of mycosynthesized zinc nanoparticles toward colon cancer and its most associative pathogen (Streptococcus gallolyticus)." THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Botany) 14.1 (2018), 133-142. Print. doi:10.5455/egyjebb.20180213061231



APA (American Psychological Association) Style

Marwa Mostafa Abdel-Aziz, Nesreen Ahmed Safwat, Basma Hamdy Amin (2018) Selective toxicity of mycosynthesized zinc nanoparticles toward colon cancer and its most associative pathogen (Streptococcus gallolyticus). THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Botany), 14 (1), 133-142. doi:10.5455/egyjebb.20180213061231