E-ISSN 2090-0503 | ISSN 1687-7497
 
2023, Vol: 19, Issue: 2
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Original Research 


MICROBIOLOGICAL AND IMMUNOLOGICAL STUDIES IN CHILDREN WITH ACUTE LYMPHOID AND MYELOID LEUKAEMIA

Saida M. Amer, Nanis G. Allam, Mohsen S. El-Alfy, Ahmed S. El-Shafey.

Abstract
Patients with acute leukaemia are predisposed to opportunistic infections. Microbiological and immunological investigations were done on patients with acute leukaemia and healthy control. Antimicrobial of cinnamon, clove, garlic and black seed oils were evaluated in vitro by an agar well diffusion assay. The most commonly isolated microorganisms were Escherichia coli, Pseudomonas aeruginosa, Salmonella typhimurium, Streptococcus pneumoniae and Candida albicans. Among infections, urinary tract infections represent 70%, septicaemia represent 20%, and gastrointestinal tract infections represent 10%. It could be concluded that gram negative bacilli were the most common infections in children with leukaemia. Also there were significant decrease in serum immunoglobulin A and complement component 3 for children with leukaemia who infected with microorganisms compared to leukaemia children who didn’t infect with microorganisms. Cinnamon oil was the best antimicrobial oil from the other used oils (garlic oil, clove oil and black seed oil) against Escherichia coli, Pseudomonas aeruginosa and Candida albicans. The present study proved that children with acute leukaemia suffered from immunodeficiency especially during chemotherapy that made them susceptible to infections. Also cinnamon oil was more effective in inhibiting growth of Escherichia coli, Pseudomonas aeruginosa and Candida albicans. Cinnamon oil could be used as alternative drug to control the microbial infections rather than antibiotics to avoid their side effects.

Key words: Microbial infections, A lymphoid, Myeloid leukaemia


 
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How to Cite this Article
Pubmed Style

Saida M. Amer, Nanis G. Allam, Mohsen S. El-Alfy, Ahmed S. El-Shafey. MICROBIOLOGICAL AND IMMUNOLOGICAL STUDIES IN CHILDREN WITH ACUTE LYMPHOID AND MYELOID LEUKAEMIA . Egypt. J. Exp. Biol. (Bot.). 2016; 12(1): 1-8.

Web Style

Saida M. Amer, Nanis G. Allam, Mohsen S. El-Alfy, Ahmed S. El-Shafey. MICROBIOLOGICAL AND IMMUNOLOGICAL STUDIES IN CHILDREN WITH ACUTE LYMPHOID AND MYELOID LEUKAEMIA . https://www.egyseb.net//?mno=216042 [Access: December 05, 2023].

AMA (American Medical Association) Style

Saida M. Amer, Nanis G. Allam, Mohsen S. El-Alfy, Ahmed S. El-Shafey. MICROBIOLOGICAL AND IMMUNOLOGICAL STUDIES IN CHILDREN WITH ACUTE LYMPHOID AND MYELOID LEUKAEMIA . Egypt. J. Exp. Biol. (Bot.). 2016; 12(1): 1-8.


Vancouver/ICMJE Style

Saida M. Amer, Nanis G. Allam, Mohsen S. El-Alfy, Ahmed S. El-Shafey. MICROBIOLOGICAL AND IMMUNOLOGICAL STUDIES IN CHILDREN WITH ACUTE LYMPHOID AND MYELOID LEUKAEMIA . Egypt. J. Exp. Biol. (Bot.). (2016), [cited December 05, 2023]; 12(1): 1-8.


Harvard Style

Saida M. Amer, Nanis G. Allam, Mohsen S. El-Alfy, Ahmed S. El-Shafey (2016) MICROBIOLOGICAL AND IMMUNOLOGICAL STUDIES IN CHILDREN WITH ACUTE LYMPHOID AND MYELOID LEUKAEMIA . Egypt. J. Exp. Biol. (Bot.), 12 (1), 1-8.


Turabian Style

Saida M. Amer, Nanis G. Allam, Mohsen S. El-Alfy, Ahmed S. El-Shafey. 2016. MICROBIOLOGICAL AND IMMUNOLOGICAL STUDIES IN CHILDREN WITH ACUTE LYMPHOID AND MYELOID LEUKAEMIA . THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Botany), 12 (1), 1-8.


Chicago Style

Saida M. Amer, Nanis G. Allam, Mohsen S. El-Alfy, Ahmed S. El-Shafey. "MICROBIOLOGICAL AND IMMUNOLOGICAL STUDIES IN CHILDREN WITH ACUTE LYMPHOID AND MYELOID LEUKAEMIA ." THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Botany) 12 (2016), 1-8.


MLA (The Modern Language Association) Style

Saida M. Amer, Nanis G. Allam, Mohsen S. El-Alfy, Ahmed S. El-Shafey. "MICROBIOLOGICAL AND IMMUNOLOGICAL STUDIES IN CHILDREN WITH ACUTE LYMPHOID AND MYELOID LEUKAEMIA ." THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Botany) 12.1 (2016), 1-8. Print.


APA (American Psychological Association) Style

Saida M. Amer, Nanis G. Allam, Mohsen S. El-Alfy, Ahmed S. El-Shafey (2016) MICROBIOLOGICAL AND IMMUNOLOGICAL STUDIES IN CHILDREN WITH ACUTE LYMPHOID AND MYELOID LEUKAEMIA . THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Botany), 12 (1), 1-8.


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